For over 20 years, Dr. Manfred Keller has put his efforts on improving patients life with his research work and innovative improvements of treatments. The following list of patents proves his outstanding work in his fields of expertise.
Methods of treating respiratory syncytial virus infections
Patent number: 10835512
Abstract: Compositions and methods for the treatment of respiratory syncytial virus infections are provided.
Type: Grant
Filed: July 10, 2019
Date of Patent: November 17, 2020
Assignee: Respivant Sciences GmbH
Inventors: Pravin Soni, William Gerhart, Manfred Keller, Ahmet Tutuncu
Mast cell stabilizers treatment for systemic disorders
Publication number: 20190307721
Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
Type: Application
Filed: May 7, 2019
Publication date: October 10, 2019
Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
Mast cell stabilizers treatment for systemic disorders
Patent number: 10398673
Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
Type: Grant
Filed: February 12, 2019
Date of Patent: September 3, 2019
Assignee: Respivant Services GmbH
Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
Dry powder for inhalation
Publication number: 20190022106
Abstract: The present invention provides dry powder formulations for inhalation having improved moisture resistance such that the powders maintain a high fine particle dosage or fine particle fraction following storage under relatively extreme temperature and humidity conditions.
Type: Application
Filed: September 21, 2018
Publication date: January 24, 2019
Inventors: Manfred Keller, Rudi Mueller-Walz
METHODS FOR THE TREATMENT OF LUNG DISEASES WITH MAST CELL STABILIZERS
Publication number: 20160346246
Abstract: Methods for the treatment of lung diseases with mast cell stabilizers are provided.
Type: Application
Filed: August 9, 2016
Publication date: December 1, 2016
Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
Aqueous compositions comprising arbekacin
Patent number: 9511143
Abstract: The invention provides aqueous liquid pharmaceutical compositions comprising arbekacin and chloride ions. The compositions are well tolerable for use in a method for treatment or prevention of a disease of the upper or lower respiratory tract, wherein the composition is aerosolized and inhaled by the patient. Furthermore, the invention provides arbekacin hydrochloride.
Type: Grant
Filed: August 3, 2012
Date of Patent: December 6, 2016
Assignees: Meiji Seika Pharma Co., Ltd., PARI Pharma GmbH
Inventors: Manfred Keller, Yukihiro Yagi, Masashi Tanaka, Toshie Sugano, Kuniko Shoji, Nao Sano, Michael Hahn, Roman Egle
Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
Patent number: 8399496
Abstract: A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.
Type: Grant
Filed: August 21, 2008
Date of Patent: March 19, 2013
Assignee: Gilead Sciences, Inc.
Inventors: Alan Bruce Montgomery, Manfred Keller, Frank-Christophe Lintzv
Disodium cromoglycate compositions and methods for administering same
Patent number: 8263645
Abstract: Methods for the treatment of patients that are afflicted with pulmonary conditions, such as a pulmonary disease are described. The methods may involve the administration of aerosolized medicines. More specifically, compositions including disodium cromoglycate (DSCG) and therapeutic methods that include the pulmonary administration of such compositions are described.
Type: Grant
Filed: February 5, 2007
Date of Patent: September 11, 2012
Assignee: PARI Pharma GmbH
Inventor: Manfred Keller
Macrolide compositions having improved taste and stability
Publication number: 20090232744
Abstract: The invention provides an aqueous pharmaceutical composition for administration as an aerosol to the respiratory tract, nose or oropharyngeal region comprising (i) a macrolide having a poor taste and poor chemical stability in aqueous solution; (ii) at least one salt selected from the group consisting of sodium gluconate, sodium aspartate, sodium acetate, sodium lactate, sodium succinate, sodium maleate, magnesium gluconate, magnesium aspartate, magnesium citrate, magnesium acetate, magnesium lactate, magnesium succinate, and magnesium maleate; or mixtures thereof and (iii) a taste-masking agent different from said salt; wherein (a) the concentration of said macrolide in the composition is in the range of about 0.25 wt.-% to about 15 wt.-%; (b) the molar ratio of said macrolide:said salt is in the range from about 1:0.5 to about 1:100; (c) the pH of the composition is in the range of about 3 to 9; and (d) the osmolality of the composition is in the range of about 150 mOsmol/kg to about 1500 mOsmol/kg.
Type: Application
Filed: February 26, 2009
Publication date: September 17, 2009
Applicant: PARI Pharma GmbH
Inventors: Manfred Keller, Evy Corbanie
Nebulised Antibiotics for Inhalation Therapy
Publication number: 20090025713
Abstract: The present invention provides pharmaceutical aerosols which are useful for the prevention or treatment of infectious diseases of the airways, such as the lungs, the bronchi, or the sinunasal cavities. The aerosols comprise an active agent selected from the group of quinolone antibiotics. Also disclosed are liquid and solid compositions suitable for being converted into the aerosols, and kits comprising such compositions.
Type: Application
Filed: February 8, 2007
Publication date: January 29, 2009
Applicant: PARI Pharma GmbH
Inventors: Manfred Keller, Aslihan Akkar
Dheas inhalation compositions
Publication number: 20090118249
Abstract
The present invention provides compositions for aqueous suspension comprising DHEAS and a divalent cation. The suspension in combination with a nebulizer or nasal pump spray can be administers as an aerosol for the treatment of respiratory diseases and conditions. The present invention also provides methods for making compositions in form of aqueous suspension of DHEA and divalent cations.
Type: Application
Filed: September 4, 2008
Publication date: May 7, 2009
Inventors: Ingo Friedrich, Manfred Keller, Stefan Kerscher
Liquid preparation containing tobramycin
Publication number: 20070071686
Abstract: The application describes a sterile aqueous inhalation solution containing the active agent tobramycin. The preparation has a high content of active agent (about 80 to 120 mg/ml of tobramycin) and contains an acidic adjuvant, but contains only a low concentration of sodium chloride (at most about 2 mg/ml). It can be injected or administered as an aerosol, for example with conventional nebuliser. It is particularly suitable for application in combination with a modern vibrating membrane nebuliser and allows the administration of a therapeutic single does in markedly less than 10 minutes.
Type: Application
Filed: October 14, 2004
Publication date: March 29, 2007
Applicant: Pari GmbH
Inventors: Frank-Christophe Lintz, Manfred Keller
Inhaler for multiple dosed administration of a pharmacological dry powder
Patent number: 7131441
Abstract: An inhaler for multiple dosed administration of a pharmacological dry powder has a housing with a mouthpiece fitted thereon and a removable protective cap that covers the mouthpiece prior to removal. The mouthpiece may be fitted with or without lip grooves, which aid a user in the positioning and manipulation of the inhaler. The inhaler includes a dosing slide, a carriage, a dosing cavity and a valve shield, all of which are arranged within the housing. Removal of the protective cap initiates dosing, which consists of a dose of a pharmacological dry powder being received in the dosing cavity and then transported to the mouthpiece by means of the dosing slide. Only upon application of a defined minimum intensity of inhalation is the shutter moved by the suctioned valve shield, resulting in the release of the dose for inhalation.
Type: Grant
Filed: May 12, 2000
Date of Patent: November 7, 2006
Assignee: SkyePharma AG
Inventors: Manfred Keller, Thomas Eggimann
Inhalation nebulizer
Publication number: 20060054166
Abstract: An inhalation nebulizer includes an aerosol generator that has a diaphragm vibrated by a vibration generator. The inhalation nebulizer includes a liquid storage container that is in fluid contact with the diaphragm. A liquid contained in the storage container is atomized into a mixing chamber through openings in the diaphragm and can subsequently be inhaled by a patient.
Type: Application
Filed: November 7, 2005
Publication date: March 16, 2006
Applicant: Pari GmbH Spezialisten fur effektive Inhalation
Inventors: Martin Knoch, Manfred Keller, Roland Stangl, Thomas Gallem, Rainer Liening-Ewert, Markus Urich
Kit for the preparation of a pharmaceutical composition
Publication number: 20040247628
Abstract: The invention relates to pharmaceutical kits for the preparation of liquid compositions which can be administered to humans as aerosols for the diagnosis, prevention or treatment of human diseases. A kit according to the invention comprises a solid composition and a sterile aqueous liquid capable of dispersing or dissolving the solid composition to form a liquid composition which can be aerosolized. The solid composition of the kit comprises one or more active compounds and a water-soluble, low molecular weight excipient. Preferably, the solid composition comprises a sugar or a sugar alcohol, such as mannitol, lactose, or glucose.
Type: Application
Filed: April 23, 2004
Publication date: December 9, 2004
Inventors: Frank-Christophe Lintz, Manfred Keller
Inhalation device and method for production of a particulate mist for inhalation purposes
Publication number: 20030164169
Abstract: The inhalation device comprises an oscillator (1), on which a powder (6) for nebulisation may be placed, containing a medicament and which may be activated in order to nebulise the applied powder, a mixing chamber (2) into which the powder particles are thrown and where an aerosol cloud (6a) is formed from incoherent particles, an inhalation check valve (3) which permits ambient air into the mixing chamber (2) during inhalation to evacuate the particle cloud (6a) and an exhalation check valve (4), by means of which expired air is led off into the environment to prevent damp breath entering the mixing chamber (2) during exhalation.
Type: Application
Filed: May 6, 2003
Publication date: September 4, 2003
Inventors: Roland Stangl, Manfred Keller
Medicinal aerosol formulations
Patent number: 6585958
Abstract: A pressure-liquefied propellant mixture for aerosols, comprising dinitrogen monoxide and a hydrofluoroalkane having 1 to 3 carbon atoms, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, makes possible an improvement in the wetting properties of pharmaceutically active compounds, whereby the formulation problems existing with hydrofluoroalkanes can be overcome with respect to suspension and solution aerosols and thus improved medicinal aerosol formulations can be obtained. With the aid of dinitrogen monoxide, it is also possible to influence the pressure and thus the particle size distribution specifically and, by displacement of oxygen from the hydrofluoroalkanes, to improve the storage stability of oxidation-sensitive active compounds. If desired, the propellant mixture can additionally contain carbon dioxide.
Type: Grant
Filed: April 13, 2001
Date of Patent: July 1, 2003
Assignee: Jago Research AG
Inventors: Manfred Keller, Kurt Herzog, Rudi Müller-Walz, Holger Kraus
Furthermore, see a list of patents Dr. Manfred Keller has developed with Pari GmbH.